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Filtered Search Results
Medchemexpress LLC Elacridar hydrochloride | 143851-98-3 | 99.8% | C34H34ClN3O5 | 5 MG
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Elacridar hydrochloride (GF120918A) is an orally active dual-inhibitor of P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP). This compound is used for research to examine the influence of efflux transporters on agent distribution to the brain and for cancer research.
- Orally active P-glycoprotein (P-gp) inhibitor
- Orally active breast cancer resistance protein (BCRP) inhibitor
- Used to examine the influence of efflux transporters on agent distribution to the brain
- Applicable for cancer research
- Inhibits cell viability of 786-O cells in vitro
- Affects P-glycoprotein and ABCG2 protein expression levels in MCF-7 and 786-O cell lines
- Increases ⁹⁹mTc-MIBI intracellular accumulation in MCF-7 and 786-O cell lines
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Yonkenafil hydrochloride | 804519-64-0 | 99.4% | 524.08 g/mol | C24H34ClN5O4S | 25MG
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Small and/or specialty supplier based on Federal laws and SBA requirements.
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Yonkenafil hydrochloride is a research-grade phosphodiesterase 5 (PDE5) inhibitor intended for preclinical and biochemical studies. The compound is supplied as a hydrochloride salt, with molecular formula C24H34ClN5O4S and molecular weight 524.08 g/mol. It is typically used as a reference or test compound in pharmacology and neurobiology research where PDE5 modulation is of interest.
- PDE5 inhibitor suitable for biochemical and cellular assays.
- Reported high purity (99.4%) for consistent experimental results.
- Available in small milligram pack sizes for assay development.
- Hydrochloride salt form for improved handling and stability.
- Molecular properties provided for formulation and dosing calculations.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Endoxifen hydrochloride | 1197194-41-4 | 98.0% | 409.95 | 5 MG
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Endoxifen hydrochloride is a key active metabolite of Tamoxifen (TAM) with higher affinity and specificity to the estrogen receptor, and it also inhibits aromatase activity. It has potential for breast cancer study.
- Key active metabolite of Tamoxifen (TAM).
- Higher affinity and specificity to estrogen receptor.
- Inhibits aromatase activity.
- Potential for breast cancer study.
- Approximately 100-fold more potent as an antagonist of the ER than tamoxifen.
- Targets estrogen receptor α for degradation in breast cancer cells.
- Blocks ERA transcriptional activity and inhibits estrogen-induced breast cancer cell proliferation.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC 4-Thiazolecarboxamide, N-(2-aminoethyl)-5-(3-fluorophenyl)-, hydrochloride (1:1) | 127917-66-2 | MFCD00900596 | 100.0% | 301.77 | C12H13ClFN3OS | 50 MG
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Ro 41-1049 hydrochloride is a reversible, selective monoamine oxidase-A (MAO-A) inhibitor supplied as a solid research reagent with high reported purity. It has documented in vitro binding (Kd ≈16.5 nM in human frontal cortex) and shown in vivo effects on dopamine metabolism. Solubility data indicate good solubility in DMSO and water. The product is provided with supporting analytical documents for quality verification.
- High reported purity suitable for research applications.
- Selective, reversible inhibition of MAO-A.
- Documented solubility in common solvents (DMSO, water).
- Provided with COA, SDS, and datasheet for quality assurance.
- Available in multiple pack sizes for experimental flexibility.
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Medchemexpress LLC Adrogolide hydrochloride | 166591-11-3 | 99.6% | 435.96 g/mol | C22H26ClNO4S | 5 MG
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Adrogolide hydrochloride is the hydrochloride salt of adrogolide, a prodrug that is converted in plasma to the dopamine D1 receptor agonist A-86929. It is provided as a research-grade compound for pharmacology and neuroscience studies where selective D1 activation is required.
- High purity suitable for research applications.
- Soluble in DMSO; documented in vivo formulation options for administration.
- Available in small and larger pack sizes to support screening and in vivo studies.
- Stable when stored dry at room temperature; stock solutions stable at -20°C to -80°C.
- Used to study dopamine D1 receptor-mediated pharmacology in vitro and in vivo.
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Medchemexpress LLC VU6036720 hydrochloride | 99.7% | 473.39 | 100 MG
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VU6036720 hydrochloride is a potent and specific in vitro inhibitor of Kir4.1/5.1 channels. It can inhibit these channels with an IC50 value of 0.24 μM and is suitable for research related to brain and kidney.
- Potent and specific in vitro inhibitor of Kir4.1/5.1 channels
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM
- Can be used for the research of brain and kidney
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Medchemexpress LLC AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
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AR-C102222 hydrochloride | 1781934-50-6 | 99.8% | 10MM 1ML
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Medchemexpress LLC Befiradol hydrochloride | 2436760-81-3 | 99.93% | 430.32 | 25 MG
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Befiradol hydrochloride is a selective 5-HT1A receptor agonist, suitable for research use only.
- Reduces activity of dorsal raphe serotonergic neurons
- Increases discharge rate of mPFC pyramidal neurons
- Decreases extracellular 5-HT in the hippocampus and mPFC
- Increases extracellular DA in mPFC
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Medchemexpress LLC Imeglimin (hydrochloride) | 775351-61-6 | 99.3% | 191.66 | 50 MG
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Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent. It also reduces reactive oxygen species (ROS) production, increases mitochondrial DNA, and improves mitochondrial function.
- Oral glucose-lowering agent
- Reduces reactive oxygen species production
- Increases mitochondrial DNA
- Improves mitochondrial function
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Medchemexpress LLC Imeglimin (hydrochloride) | 775351-61-6 | 99.98% | 191.66 | 5 MG
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Imeglimin hydrochloride is an oral glucose-lowering agent. It functions by reducing reactive oxygen species (ROS) production, increasing mitochondrial DNA, and improving mitochondrial function.
- Oral glucose-lowering agent.
- Reduces reactive oxygen species (ROS) production.
- Increases mitochondrial DNA.
- Improves mitochondrial function.
- Prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.
- Significantly decreases hyperglycemia and restores normal glucose tolerance in models.
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Medchemexpress LLC VU6036720 hydrochloride | 99.65% | 473.39 | 50 MG
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VU6036720 hydrochloride is a potent and specific inhibitor of Kir4.1/5.1 channels. It is suitable for various research applications.
- Inhibits Kir4.1/5.1 channels with an IC50 value of 0.24 μM.
- Can be used for the research of brain and kidney.
Non-distribution item offered as a customer accommodation; additional freight charges may apply.
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Medchemexpress LLC Imeglimin (hydrochloride) | 775351-61-6 | 99.3% | 191.66 | 25 MG
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Imeglimin hydrochloride (EMD 387008) is an oral glucose-lowering agent that reduces reactive oxygen species (ROS) production, increases mitochondrial DNA, and improves mitochondrial function. This compound appears as a white to off-white solid.
- Oral glucose-lowering agent
- Reduces reactive oxygen species (ROS) production
- Increases mitochondrial DNA
- Improves mitochondrial function
- Soluble in H2O (≥ 50 mg/mL)
- Soluble in DMSO (25 mg/mL)
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Medchemexpress LLC Flavoxate hydrochloride (Standard) | 3717-88-2 | 99.7% | 100 MG
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Flavoxate hydrochloride (Standard) | 3717-88-2 | 99.7% | 100 MG
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Medchemexpress LLC Arg1-in-1 (hydrochloride) | 00-00-0 | 90.0% | 292.57 g·mol⁻1 | C11H22BClN2O4 | 5 MG
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ARG1-IN-1 hydrochloride is a small-molecule inhibitor of human arginase 1 with a reported IC50 of 29 nM. It is intended for research use in biochemical and cellular studies to probe arginase-related pathways. The hydrochloride form improves handling and aqueous compatibility for assay preparation.
- Potent arginase 1 inhibition (IC50 29 nM).
- Suitable for biochemical and cellular assays.
- Provided as a 5 mg quantity for small-scale research use.
- Molecular weight 292.57 g·mol⁻1; formula C11H22BClN2O4.
- Purity typically 90.0% as reported on the certificate of analysis.
- Store at -20°C under nitrogen and protect from moisture; in solvent store at -80°C for long-term.
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Medchemexpress LLC CP-640186 (hydrochloride) | 591778-70-0 | C30H36ClN3O3 | 100 MG
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CP-640186 hydrochloride is an orally active and cell-permeable inhibitor of Acetyl-CoA carboxylase (ACC). It exhibits IC50 values of 53 nM for rat liver ACC1 and 61 nM for rat skeletal muscle ACC2. ACC is a crucial enzyme involved in fatty acid metabolism, responsible for synthesizing malonyl-CoA. This compound also promotes muscle fatty acid oxidation.
- Orally active and cell-permeable.
- Inhibits Acetyl-CoA carboxylase (ACC).
- IC50s: 53 nM for rat liver ACC1, 61 nM for rat skeletal muscle ACC2.
- Stimulates muscle fatty acid oxidation.
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